A method for automatic registration of landmarks in 3D and 2D images of an organ comprises: using a first set of coordinates of identified first, second and third landmarks of the organ, derived from a 3D surface representation of the organ, and a second set of coordinates of the landmarks, derived from 2D laparoscopic images of the organ, to register the three landmarks as identified in the 3D surface representation with the three landmarks as identified in the 2D images. The third landmark comprises a plurality of points defining a path between two points characterizing the first and second landmarks The identification of the first, second and third landmarks in the 3D representation and the 2D images, the derivation of the first and second sets of coordinates, and the registration, based on the derived first and second sets of coordinates, are performed automatically.
