Katherine A. Chu,Elena T. Chan,Ying Fang,Mouhannad Jamaa,Christopher Justin Kirk,Tony Muchamuel,Zhengping Wang,Jing Jiang,Jeffrey Joseph Jones
申请号:
US14414363
公开号:
US20150209281A1
申请日:
2013.07.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions provide prolonged drug exposure (relative to non-liposomal compositions comprising peptide epoxyketone compounds) without significantly affecting biodistribution of the drug. Tolerability of peptide epoxyketone compounds was also enhanced when formulated in the liposomal compositions.