The present inventions concerns derivatives of aminocyclobutane, particularly as NMDA receptor antagonists, their application in human therapy and their method of preparation.These compounds correspond to the general formula (1): wherein: - X1 represents a hydrogen atom or fluorine atom； - X2 is a hydrogen atom or fluorine atom or chlorine atom； - R1 represents a hydrogen atom or fluorine atom or chlorine atom or methyl group or methoxy group or cyano group； - R2 represents independently or together a methyl group or ethyl group.本發明關注胺基環丁烷之衍生物，特別是作為NMDA受體拮抗劑，其在人類醫療中之應用，及其製備方法。這些化合物對應於通式(1)：其中：- X1代表氫原子或氟原子；- X2為氫原子或氟原子或氯原子；- R1代表氫原子或氟原子或氯原子或甲基或甲氧基或氰基；- R2獨立地或一起代表一甲基或乙基。
