A method, medium, and apparatus measuring biological signals using a multi-electrode module, with a lead search method. An apparatus for measuring biological signals by using a multi-electrode module, includes a multi-electrode module having a non-conductive patch and a sensor array including a ground electrode and a plurality of individual electrodes, an electrode selection unit selecting a plurality of electrode pairs including a reference electrode and a measurement electrode from the plurality of individual electrodes depending on a type of the biological signal to be measured, and a signal processing unit for obtaining the biological signals from the plurality of electrode pairs.
