Goldsborough, Andrew Simon;Bates, Malcolm Robert;Goldsborough; Andrew Simon
发明人:
申请号：
EP14708231.7
公开号：
EP2961268B1
申请日:
2014.02.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided is a use of a deep eutectic solvent to inhibit the degradation of a biomolecule, wherein the biomolecule is a protein. The deep eutectic solvent comprises a first component and a second component. The first component is a compound of Formula I: wherein: R 6 is H or OH； R 7 is selected from H, CH 3 , Cl, Br, a carbonyl oxygen, and Z is selected from -CH 2 -, O and S； and R 8 is R 11 or OH. The second component comprises a compound of Formula II or a salt thereof: wherein: A is selected from O, S, and NH； R 1 is selected from R 9 and -C(R 3 )(R 4 )(R 5 )； R 2 is selected from H and linear alkyl group having 1 to 3 carbon atoms； R 3 is an optionally substituted 5- or 6-membered aliphatic or aromatic ring, wherein the substituent is R 10 ； R 4 and R 5 are F. R 9 is a mono-, di- or trifluoromethyl group or a mono-, di- or tri-fluoroethyl group； and R 10 and R 11 are each independently selected from alkyl groups having one to three carbon atoms, monochloroalkyl groups having one to three carbon atoms, and mono-, di- or tri-fluoroalkyl groups having one to three carbon atoms.
