KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES;한국원자력의학원
发明人:
LEE, Kee Ho,이기호,SHIN, Hyun Jin,신현진,JUNG, Won Hee,정원희,SONG, Jie Young,송지영,LEE, Eun Ju,이은주,HAM, Yong Ho,함용호,KIM, Sung Sub,김성섭,HONG, Sung Hee,홍성희
申请号：
KRKR2016/009118
公开号：
WO2017/030394A1
申请日:
2016.08.18
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
A clustered mitochondrial homolog (CLUH) or a BMP binding endothelia regulator (BMPER) according to the present invention is involved in differentiation into adipocytes and fat accumulation. Thus, by inhibiting the CLUH or the BMPER, differentiation into adipocytes can be inhibited and obesity can be treated or prevented. Also, by measuring the level of expression of the CLUH or the BMPER, obesity can be diagnosed and screening of an obesity treating agent or a control agent for differentiation into adipocytes is enabled.La présente invention concerne un homologue mitochondrial aggloméré (CLUH, clustered mitochondrial homolog) ou un régulateur de l'endothélium se liant à la BMP (BMPER) qui est impliqué dans la différenciation en adipocytes et l'accumulation de graisse. Ainsi, en inhibant le CLUH ou le BMPER, la différenciation en adipocytes peut être inhibée et l'obésité peut être traitée ou prévenue. En outre, en mesurant le niveau d'expression du CLUH ou du BMPER, l'obésité peut être diagnostiquée et le criblage d'un agent de traitement de l'obésité ou d'un agent de régulation de la différenciation en adipocytes est possible.본 발명의 CLUH (Clustered mitochondrial homolog) 또는 BMPER (BMP binding endothelial regulatr)은 지방세포로의 분화 및 지방 축적에 관여하므로, 이를 억제하여 지방 세포로의 분화를 억제할 수 있으며, 비만을 치료 또는 예방할 수 있다. 또한, 상기 CLUH 또는 BMPER의 발현 수준을 측정하여 비만을 진단하고, 비만 치료제, 및 지방세포로의 분화 조절제를 스크리닝할 수 있다.
