The present invention relates to compounds of formula wherein X, R, L, Ar, R1 and n are as defined herein, or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson’s disease, neurodegenerative disorders, Alzheimer’s disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.本發明係關於一種式I之化合物,其中x、R、L、Ar、R1及n如本文中所定義,或其醫藥上合適之酸加成鹽、所有外消旋混合物、所有其等相應之鏡像異構物及/或光學異構物,其等可用於治療抑鬱症、焦慮症、躁鬱症、注意力不足過動症(ADHD)、壓力相關障礙症、精神性失常、精神分裂症、神經性疾病、帕金森氏病、神經退行性疾病、阿茲海默氏病、癲癇、偏頭痛、高血壓、藥物濫用、代謝失調、飲食障礙症、糖尿病、糖尿病併發症、肥胖症、異常血脂症、能量消耗及同化失調症、體溫穩衡失調症及功能障礙、睡眠及晝夜節律性異常及心血管疾病。
