CARDONA, Claudia M.,KETNER, Mark Ennis,CHINTA, Dakshinamurthy Devanga,SAHI, Carl R.,POLIDORO, John M.,GLADDEN, James-Thomas Marion
申请号：
EP17821086
公开号：
EP3474826A4
申请日:
2017.06.27
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided herein is a composite microparticle for oral delivery of an active agent to a subject. The microparticles are general in the form of self-sustaining bodies comprising a crosslinked polymer matrix and a plurality of emulsion droplets distributed throughout. The active agent is encapsulated in the emulsion droplets. A plurality of delivery enhancing moieties are presented on the exterior surface of said self-sustaining body and/or on the emulsion droplets. The microparticle is resistant to enteric degradation and will localize in the gastrointestinal tract of the subject without crossing the intestinal mucosa into the intestinal bloodstream.
