The invention relates to the treatment of cancer using DNA damaging agents. The invention provides methods for treating a mammal with cancer, the method comprising inhibiting in the mammal acidic residue methyltransferase (Arm1) in combination with administering to the mammal a DNA damaging agent. The invention further provides pharmaceutical formulations comprising an inhibitor of acidic residue methyltransferase (Arm1) and a DNA damaging agent.La présente invention concerne le traitement du cancer au moyen dagents lésant lADN. Linvention concerne des méthodes de traitement dun mammifère souffrant dun cancer, ladite méthode comprenant linhibition chez un mammifère de la méthyltransférase Arm1, inhibition combinée à ladministration dun agent lésant lADN. Linvention concerne, en outre, des formulations pharmaceutiques comprenant un inhibiteur de la méthyltransférase Arm1 et un agent lésant lADN.
