Ivan M. Borrello,Kimberly A. Noonan,Leonido Luznik
申请号：
US14647358
公开号：
US20150320798A1
申请日:
2013.11.26
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to the field of cancer therapy. More specifically, the present invention provides methods and compositions useful for augmenting anti-tumor immunity. In one embodiment, a method for treating or preventing post-allogeneic transplant relapse in a subject who has received post-transplant cyclophosphamide treatment comprises the steps of (a) obtaining a bone marrow sample from the subject； (b) expanding the marrow infiltrating lymphocytes (MILs) present in the sample； and (c) administering the MILs to the subject. In a specific embodiment, the method significantly reduces the likelihood of developing GVHD.
