A compound represented by the following general formula (I), its salt,solvatesthereof or prodrugs thereof:(see formula I)(wherein each symbol is as defined in the description.) The compoundsrepresented bythe general formula (I) are useful in preventing and/or treating variousinflammatorydiseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoidarthritis, rhinitis,conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmunediseases,rejection in organ transplantation, immunosuppression, psoriasis, multiplesclerosis, etc.),infection with human immunodeficiency virus (acquired immunodeficiencysyndrome,etc.), allergic diseases (atopic dermatitis, urticaria, allergicbronchoplumonary aspergillosis,allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury,acute respiratorydistress syndrome, shock accompanying bacterial infection, diabetes, cancermetastasis andso on.
