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油膜包覆腸溶劑型結構
专利权人:
WEI-CHIH;CHANG
发明人:
CHANG, WEI CHIH,张伟智,張偉智
申请号:
TW102202922
公开号:
TWM464179U
申请日:
2013.02.08
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
A kind of oil film cladding enteric dosage form construct,Its dosage form system include a shell and a core space with and a content,Have several drug molecules in what core space in what content system packet,The wherein one ester matter oil lamella of drug molecule system what external sheath of content,Make ester matter oil lamella coating medicine molecule can be formed carrier for protection small molecule medicine active delivery to small intestine protection film layer,Contain the characteristic that ester prime factor coating medicine molecule can emulsify in conjunction with human bile and the content in packet in what dosage form is made to keep activity by ester matter oil lamella,Dosage form is enabled not decomposed by gastric acid by the drug molecule that gastric acid disintegration shell Hou can possess content,And the ester matter oil lamella entered before small intestine emulsifies Hou in conjunction with bile,Therefrom the drug molecule of content is able to protect its activated state and pharmaceutical activity can be made to enter small intestine alimentary canal to decompose in emulsification Hou output blood of human body and reach the state of optimization and promote the edible absorptivity of dosage form,And reach the edible purpose that can be reduced stimulation stomach and protect stomach health of dosage form.一種油膜包覆腸溶劑型結構,其劑型係包含有一殼層及一核心空間與及一內容物,於內容物係包裏於核心空間內而具若干藥物分子,其中內容物之藥物分子係於外層包覆一酯質油膜層,使酯質油膜層包覆藥物分子可形成載體供保護小分子藥活性輸送至小腸之防護膜層,藉由酯質油膜層含有酯質因子包覆藥物分子可與人體膽汁結合乳化而使包裏於劑型內之內容物保持活性之特性,令劑型通過胃酸崩解殼層後可保有內容物之藥物分子不被胃酸分解,且進入小腸前之酯質油膜層與膽汁結合乳化後,從中內容物之藥物分子得以保其活性狀態並可使藥物活性進入小腸消化道分解乳化後輸出人體血液中而達到最適化之狀態與提升劑型食用之吸收率,且達到劑型食用可減少刺激胃部與保護胃部健康之目的。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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