The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug； at least one preservative； and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.本發明係有關於可注射的藥學組合物、其使用方法及其配方，其中該組合物包含：一或多個水溶性複合物，各包含一環糊精或環糊精衍生物，以及一疏水性藥物；至少一防腐劑；以及至少一共溶劑。依據2011年歐洲藥典中對於抗菌保存功效的測試，且至少是非腸道的B標準，以及美國藥典2011年指南中對於第1類(注射用)產品的抗菌效果測試，該組合物係經有效保存。
