The present invention relates to the compositions of the pH injectable aqueous solutions form for being 6.0 to 8.0, include at least: a) basal insulin, and isoelectric point pI is 5.8 to 8.5； And it b) is copolymerized (amino acid), replaced with carboxylic acid load and by hydrophobic grouping. In one embodiment, insulin and/or gastrointestinal hormone when composition according to the present invention also includes meal.本發明涉及pH爲6.0至8.0的可注射水溶液形式的組合物，其至少包含：a)基礎胰島素，其等電點pI爲5.8至8.5；以及b)共聚（氨基酸），其具有羧酸荷載並且被疏水基團取代。在一個實施方案中，根據本發明的組合物還包含餐時胰島素和／或胃腸激素。
