PROBLEM TO BE SOLVED: To provide a compound that treats and/or prevents synuclein diseases by specifically inhibiting the formation of a propagating dimer and a toxic SYN oligomer.SOLUTION: The compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. [R1 and R3 are each independently a substituted/unsubstituted, aromatic or cycloaliphatic heterocyclic or carbocyclic ring R2 is a 1-18C alkyl or a substituted/unsubstituted cycloalkyl or aryl L is a single bond, a 1-6C alkyl, NHCO, O, S, NHCONH or NHCOO X, Y and Z are each independently O, N, NH, S or CH and W is a single bond or a 1-6C alkyl.]SELECTED DRAWING: Figure 1COPYRIGHT: (C)2016,JPO&INPIT【課題】成長性ダイマー及び毒性SYSオリゴマーの形成を特異的に阻害して、シヌクレイン病を治療及び/又は予防する化合物の提供。【解決手段】式(I)で表される化合物又はその薬学的に許容される塩或いは溶媒和物。[R1及びR3は各々独立に置換/非置換の芳香族又は脂環式複素或いは炭素環;R2はC1~18のアルキル又は置換/非置換のシクロアルキル或いはアリール;Lは単結合、C1~6のアルキル、NHCO、O、S、NHCONH又はNHCOO;X、Y及びZは各々独立にO、N、NH、S又はCH;Wは単結合又はC1~6アルキル]【選択図】図1
