Centre National de la Recherche Scientifique (CNRS)
发明人:
Briand, Jean Paul,Hovanessian, Ara,Hamma, Yamina,Guichard, Gilles,Courty, Jose
申请号：
AU2007245551
公开号：
AU2007245551B2
申请日:
2007.04.27
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to the use of a polyvalent synthetic compound comprisinga support on which at least 3 pseudopeptide units are grafted, said compound beingof formula (I), in which each X independently represents any amino acid； Yand Yare selected independently from amino acids having a basic sidechain； Z is selected from a proline, optionally substituted at ≠, - or..； a natural or non-natural N-alkylamino acid； a dialkylamino acid； a cyclicdialkylamino acid； pipecolic acid or a derivative thereof； n and i independentlyare 0 or 1； m is an integer between 0 and 3； k is an integer greater than or equal to3； and Ψ represents a modified peptide bond which is significantly moreresistant to at least one protease than a standard peptide bond, for preparinga medicament intended for treating a disease involving deregulation of cellproliferation and/or of angiogenesis, and preferably acting as a surface nucleolinligand, or for treating inflammatory diseases.
