PROBLEM TO BE SOLVED: To provide a compound having PGEproduction inhibitory effect and NO-releasing ability and being effective in prevention/treatment of urine collection symptoms, urination symptoms and the like of lower urinary tract symptoms.SOLUTION: The compound is represented by general formula (1). Pharmaceutically acceptable salts, hydrates and solvates thereof are also provided. In the formula: Ris a hydrogen atom or -CHY-(CH)m-CH(ONO)-Y； Ris a hydrogen atom, a nitro group, or -C(=O)-(CH)n-CH(ONO)-Y； Y, Y, and Yare independently selected from a hydrogen atom, a 1-6C lower alkyl group, -CH(ONO), and -CH(ONO)-CH； m is an integer of 0-4 in each position； and n is an integer of 0-3 in each position.【課題】ＰＧＥ２産生抑制作用及びＮＯ放出能を有し、下部尿路症状の蓄尿症状、排尿症状等の予防及び／又は治療に有効な化合物の提供。【解決手段】下記一般式（１）［上記式中、Ｒ１、Ｒ２の定義は明細書記載のとおり］で表される化合物、その医薬上許容される塩、並びにそれらの水和物及び溶媒和物。
