Relates to a derivative and arylalkyl sulfonamides particular, here, its derivatives and the aryl alkyl sulfonamides, in particular, the survival of osteoclasts and inhibit the formation and activity or / and / or the present invention, bone to suppress the absorption. More specifically, the formula (I) [wherein, the Ar 1, independently, C 5-20 aryl (eg, carbazolyl biphenyl, phenanthryl, fluorenyl or, most preferably, biphenyl) The present invention is, Also, may be optionally substituted independently, H, acyl, C 5-20 aryl--C 1-7 alkyl, R N is, also, a C 1-7 alkyl or C 3-20 heterocyclyl may be optionally substituted but also, a C 2-10 alkylene group which may optionally be substituted with R alk is and, independently, Q is, or is -H , (for example, groups oxy form, and a group of amine type) and] is an organic linking group containing 1 to 30 atoms selected carbon, nitrogen, oxygen, sulfur, phosphorus, fluorine, chlorine, bromine and iodine and prodrugs form is protected pharmaceutically acceptable salt thereof and a compound represented by, solvates, amides, esters, ethers, chemically. Furthermore, it also relates to pharmaceutical compositions containing such compounds, as well as treatment of bone diseases such as Pagets disease and bone disease associated with osteoporosis, rheumatoid arthritis, cancer, and the invention, and / or, in the treatment of conditions associated with activation of the immune system, both in vitro and in vivo survival of osteoclasts to inhibit the activity, and, osteoclasts and / or mediated by the generation and / or inflammation or relates to suppress a condition characterized by bone resorption, to the use of such compounds and compositions.本発明は、特定のアリールアルキルスルホンアミド及びその誘導体に関し、ここで、該アリールアルキルスルホンアミド及びその誘導体は、とりわけ、破骨細胞の生存、生成及び/若しくは活性を抑制し、並びに/又は、骨吸収を抑制する。本発明は、より詳細には、式(I)[式中、Ar1は、独立して、C5-20アリール(例えば、ビフェニル、フェナントリル、フルオレニル又はカルバゾリル、最も好ましくは、ビフェニル)であり、また、場合により置換されていてもよい;RNは、独立して、H、アシル、C5-20アリール-C1-7アルキル、C3-20ヘテロシクリル又はC1-7アルキルであり、また、場合により置換されていてもよい
