The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+biosynthesis,e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.本發明揭示能夠調節α-胺基-β-羧基己二烯二酸半醛去羧酶(ACMSD)之活性之化合物，其適用於預防及/或治療與NAD+生物合成中之缺陷相關之疾病及病症，例如代謝病症、神經退化性疾病、慢性發炎疾病、腎病及與衰老相關之疾病。本申請案亦揭示包含該等化合物之醫藥組合物及該等化合物作為藥劑的用途。
