A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof:wherein X represents a phenylene group； Y represents a hydrogen atom, —(CH2)mR1 or the like； R1 represents —NR5COR2, —NR5SO2R2 or —NR3R4； R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group； R3 and R4 represent a C1-C6 alkyl group and the like； R5 represents a hydrogen atom or a C1-C6 alkyl group or the like； m indicates an integer of from 0 to 4； and Z represents a hydrogen atom or a C1-C6 alkyl group.
