A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof: wherein X represents a phenylene group Y represents a hydrogen atom, -(CH2)mR1 or the like R1 represents -NR5COR2, -NR5S02R2 or -NR3R4 R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group R3 and R4 represent a C1-C6 alkyl group and the like R5 represents a hydrogen atom or a C1-C6 alkyl group or the like m indicates an integer of from 0 to 4 and Z represents a hydrogen atom or a C1-C6 alkyl group.