A kind of pathological change searching device, include a fixture, and one of installation what fixture ultrasound scanner head and a bracketing body, fixture includes a retractable gripping section, the gripping section, which has to put with respect to pivot, clips the first clamping part of one of internal organs and one second clamping part, and the first clamping part is equipped with mounting hole of the opening towards the second clamping part. The ultrasound scanner head is to install fixed the second clamping part of what, which is the first clamping part of installation what for covering the mounting hole, and the ultrasonic partial penetration of ultrasound scanner head transmitting and part can be made to reflect. It is designed through the structure for installing the bracketing body and ultrasound scanner head on what fixture, so that pathological change searching device of the present invention can accurately and quickly orient organ disease position, helps what and shorten operation time-histories.一種病變搜尋裝置,包含一夾具,及安裝於夾具之一超音波探頭與一撐托體,夾具包括一可開合之夾持段,該夾持段具有可相對樞擺夾抵臟器之一第一夾持部與一第二夾持部,第一夾持部穿設有一開口朝向第二夾持部之安裝孔。該超音波探頭是安裝固定於第二夾持部,該撐托體是覆蓋該安裝孔的安裝於第一夾持部,並可使超音波探頭發射之超音波部分穿透與部分反射。透過於夾具上安裝該撐托體與超音波探頭之結構設計,使得本發明病變搜尋裝置可準確且快速地定位出臟器病變部位,有助於縮短手術時程。