Lloyd S. Gray,Timothy L. MacDonald,Doris M. Haverstick,Jaclyn R. Patterson,William F. McCalmont
申请号：
US11660693
公开号：
US09212127B2
申请日:
2005.08.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels,whereinR1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxyZ is NH, NCH3, O, S, or CH2Y is NH, O, or CH2 with the proviso that Y and Z are not the sameR2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxym and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9 andR3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.
