INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;THE BRIGHAM AND WOMENS HOSPITAL
发明人:
PIER, GERALD B.,GERALD B. PIER,MAIRA-LITRAN, TOMAS,TOMAS MAIRA-LITRAN
申请号：
PL377145
公开号：
PL229487B1
申请日:
2003.11.12
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo. The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections.
