FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel derivative of vitamin D3, suitable as therapeutic means against osteoporosis, presented by formula (1) (2), where R1 represents hydrogen atom, alkyl group with 1-6 carbon atoms, alkylcarbonyloxyalkyl group, and each alkyl has 1-6 carbon atoms, or arylcarbonyloxyalkyl group, and aryl has 6-10 carbon atoms and alkyl has 1-6 carbon atoms or together with other R2 and carbon atom, which they are bound to, can form cyclic alkyl group with 3-6 carbon atoms； R3 represents alkyl group with 1-6 carbon atoms or together with other R3 and carbon atom, which they are bound to, can form cyclic alkyl group with 3-6 carbon atoms； X represents oxygen atom or methylene group； and n is equal to integer number 1 or 2.EFFECT: invention relates to pharmaceutical composition, possessing affinity to vitamin D receptor (VDR), which contains compound of formula (1)； as well as relates to intermediate compound, represented by formula (2), in which R2, X and n are such, as given above, R4 represents R1 in formula (1), methoxymethyl group, methoxyethoxymethyl group, tetrahydrofuranyl group, tetrahydropyranyl group or benzyloxymethyl group； and R5 represents protective group for hydroxyl group, selected from the group, which includes methoxymethyl group, acyl group with 1-3 carbon atoms (mentioned number of carbon atoms includes carbonyl carbon), trimethylsilyl group, triethylsilyl group, tret-butyldimethylsilyl group and tret-butyldiphenylsilyl group.12 cl, 4 tbl, 14 exИзобретение относится к новому производному витамина D3, применимому в качестве терапевтического средства против остеопороза, которое представлено формулой (1), где R1 представляет собой атом водорода, алкильную группу с 1-6 атомами углерода, алкилкарбонилоксиалкильную группу, причем каждый алкил имеет 1-6 атомов углерода, или арилкарбонилоксиалкильную группу, причем арил имеет 6-10 атомов углерода и алкил имеет 1-6 атомов углерода； R2 представляет собой ат
