EKTA SETH CHHABRA,JOHN KULMAN,PEI-YUN CHANG,ROBERT T. PETERS,TONGYAO LIU
申请号：
BR112015000267
公开号：
BR112015000267A2
申请日:
2013.07.10
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
abstract: title "factor viii complex with xten and von willebrand protein factor, and uses thereof" the present invention includes a chimeric protein comprising a vwf protein with a domain and d3 domain ofvwf, one or more xten sequence, and a fviii protein, wherein the vwf fragment, the xten sequence, or the protein is linked to or associated with each other. the chimeric protein can further comprise one or more constant region or a portion thereof (e.g., an region). a polypeptide chain of a vwf fragment is associated with a fviii polypeptide chain linked to an xten sequence. the vwf fragment polypeptide chain can prevent or inhibit binding of endogenous vwf tofviii protein linked to the xten sequence. by preventing or inhibiting binding of endogenous vwf to fviii protein, vwf fragment can extend half-life of chimeric protein including fviii protein. The invention includes nucleotides, vectors, host cells, use of vwf fragment, or chimeric proteins. Complex Summary of Factor viii with xten and von willebrand factor protein and uses thereof The present invention provides a chimeric protein comprising a vwf protein comprising vwf d 'and d3 domain, one or more xten sequences, and a protein fviii, wherein the vwf fragment, xten sequence, or fviii protein are linked to or associated with each other. the chimeric protein comprises one or more regions of ig or a portion thereof (e.g., an fc region). A polypeptide chain comprising a vwf fragment of the invention binds to or is associated with a polypeptide chain comprising a fvii protein linked to an xten sequence and a polypeptide chain comprising the vwf fragment can prevent or inhibit endogenous vwf binding to the protein was linked to the xten sequence. To prevent or inhibit the binding of endogenous vwf to the fviii protein, which is a half-life limiting factor for fviii, the vwf fragment can induce the half-life extension of the chimeric protein comprising a fviii protein. The invention further includes nucleotides, ve
