Chang Gung Memorial Hospital, Linkou;Chang Gung University
发明人:
Ching-Chi CHIU,Tu-Hsueh YEH,Hung-Li WANG
申请号：
US16527152
公开号：
US20200215204A1
申请日:
2019.07.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed is a (D331Y) PLA2G6 knockin mouse, which shows similar clinical symptoms to those of patients suffering from Parkinson's disease (PD), and begins to display early-onset cell death of dopaminergic neurons in its substantia nigra (SN), synucleinopathy, and tau pathology at the age of about 6 months, wherein the dopaminergic neurons exhibit mitochondrial structural abnormality and dysfunction. Treatment of the (D331Y) PLA2G6 knockin mouse with L-Dopa shows a good response. The (D331Y) PLA2G6 knockin mouse can be used as a platform for developing a medicament and method for treating PD.
