Timothy James Grattan;Geoffrey Douglas Clarke;Ian Burnett
发明人:
Geoffrey Douglas Clarke,Timothy James Grattan,Ian Burnett
申请号：
US13055477
公开号：
US08604084B2
申请日:
2009.07.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is directed to a novel method for reducing intrapatient variability in pharmaceutically active agent which is suitably not absorbed in the stomach, such as paracetamol, containing formulations in patients having gastric dysmotility, or a method of improving analgesia in a diabetic patient, or improving absorption of an active agent is a patient with gastric dysmotility, which methods comprises administering orally to said patient in need thereof a pharmaceutical dosage form comprising a first active agent, calcium carbonate, at least one first binding agent, and at least one disintegrating agent as intragranular components in the form of a granulate, and as an extragranular component at least one hydrophilic colloid, an optionally a second binding agent, calcium carbonate, a super disintegrant, and a second active agent.
