An emesis containment system is configured to attach to the face of a wearer in order to contain emesis ejected from the wearer's mouth and/or nose without necessitating the wearer, or any other party, to use their hands to hold, guide, or otherwise interact with the system during use. The emesis containment system comprises a rigid or semi-rigid mask configured to attach to the user's face and a flexible bag attached to the mask. The system including the mask and flexible bag move with the wearer's head, and emesis ejected from the wearer's mouth and/or nose is directed into the flexible bag.