LUIS G. BORGES,MARK L. MICHAELS,WEI YAN,MARTIN J. PENTONY
申请号：
ARP140101239
公开号：
AR095614A1
申请日:
2014.03.17
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
The nucleic acid encoded for these antibodies, the method of making these antibodies, and the method of using these antibodies. These antibodies consist of two different polypeptide chains, each composed of two different immunoglobulin regions, and the other is the life expectancy group. Requirement 1: a double heteroantigen, including (a) the first polymer chain with formula: v1-l-12 2-ch1,When V1 and V2 are variable regions of immunoglobulin, L1 and L2 are connectors, L2 may or may not exist, and ch1 is a continuous heavy chain region of the first immunoglobulin； and (b) the second polypeptide chain, whose formula is v3-l3-v83088-l830888-cl； V3 and v83088 are connectors of variable regions such as immunoglobulin, L3 and l830808. L830808 may or may not exist, while ll is a fixed light chain region of immunoglobulin, one or two of them, In the first and second multifunctional chains, there is also (n) an average life extension group which is common under the areas (a) and (b).Where you goYou,football clubV83088 has different amino acid sequences, where different double biological antibodies break down through the nucleus of a white blood cell and display the white blood cell protein through immune injection cells, But we can't cut off a cell without leukocyte protein by immunoinjection Claim 53: a method of treating cancer patients, including effective treatment of heterosexual antibodies in any of the requirements of 1-48,Where the leukocyte protein is an antigen cancer cell. Claim 61: pharmaceutical ingredients for cancer treatment, including different BiAbs required by any one of the 1 to 48 requirements.Ácidos nucleicos que codifican para dichos anticuerpos, métodos para hacer dichos anticuerpos, y métodos para usar dichos anticuerpos. Estos anticuerpos comprenden dos cadenas polipeptídicas diferentes, en donde cada una comprende dos regiones variables de inmunoglobulina y, opcionalmente, un grupo de extensión de la vida media. Reivindicación 1: Un anticuerpo he
