1. A monoclonal antibody that binds to Notch2 NRR and inhibits Notch2 activity, where the antibody binds to Notch2 NRR with Kd≤10 nM. ! 2. The antibody according to claim 1, where the antibody essentially does not bind to representatives of the Notch family other than Notch2. ! 3. The antibody according to claim 1, where the antibody binds to mouse Notch2 NRRs and human Notch2 NRRs. ! 4. The antibody according to claim 1, where the antibody contains:! (a) an HVR-H1 comprising an amino acid sequence that corresponds to the consensus sequence of SEQ ID NO: 3； ! (b) an HVR-H2 containing the amino acid sequence of SEQ ID NO: 4； ! (c) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 5； ! (d) an HVR-L1 comprising an amino acid sequence that corresponds to the consensus sequence of SEQ ID NO: 10； ! (e) an HVR-L2 comprising an amino acid sequence that corresponds to the consensus sequence of SEQ ID NO: 14； and! (f) an HVR-L3 containing an amino acid sequence that corresponds to the consensus sequence of SEQ ID NO: 19.! 5. The antibody according to claim 4, where the antibody contains HVR-H1 containing the amino acid sequence selected from SEQ ID NO: 1-2； An HVR-L1 comprising an amino acid sequence selected from SEQ ID NO: 6-9； An HVR-L2 comprising an amino acid sequence selected from SEQ ID NO: 11-13； and HVR-L3 containing the amino acid sequence selected from SEQ ID NO: 15-18. ! 6. The antibody according to claim 5, where HVR-H1 contains the amino acid sequence of SEQ ID NO: 1, HVR-L1 contains the amino acid sequence of SEQ ID NO: 6, HVR-L2 contains the amino acid sequence of SEQ ID NO: 11 and HVR-L3 contains the amino acid the sequence of SEQ ID NO: 15.! 7. The antibody according to claim 5, where HVR-H1 contains the amino acid sequence of SEQ ID NO: 2,1. Моноклональное антитело, которое связывается с NRR Notch2 и ингибирует активность Notch2, где антитело связывается с NRR Notch2 с Kd≤10 нМ. ! 2. Антитело по п.1, где антитело по существу не связывается с предс
