The present invention provides a tablet of sporoderm-removed Ganoderma lucidum spore, which includes the following raw materials by weight parts: 13-20 parts of an aqueous extract of sporoderm-disrupted Ganoderma lucidum spore powder, 3-5 parts of sorbitol, and 0.8-1.2 parts of povidone K30； A method for preparing the tablet of sporoderm-removed Ganoderma lucidum spore includes the following steps: mixing the aqueous extract of sporoderm-disrupted Ganoderma lucidum spore powder, sorbitol and povidone K30 for 10-30 min, and subjecting the obtained mixture to granulating, screening and drying to obtain a granular material； and tableting the granular material to obtain the tablet of sporoderm-removed Ganoderma lucidum spore. The tablet of sporoderm-removed Ganoderma lucidum spore has a much higher content of active components, which are also easier to be absorbed. The tablet of sporoderm-removed Ganoderma lucidum spore is of effectively enhancing the body immunity and have anti-radiation and anti-tumor effects； and the dosage form of the tablet is convenient to carry and take.
