Elizabeth Ann Vasievich,Weihsu Claire Chen,Kenya N. Toney Johnson,Gregory Conn,Frank Bedu-Addo,Leaf Huang
申请号：
US15702063
公开号：
US20180015114A1
申请日:
2017.09.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I)； wherein in R1 is a quaternary ammonium group, Y1 is a spacer chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combinations thereof.
