Fusion protein of matrix metalloproteinase-2 inhibitor peptide derived from β-amyloid precursor protein and tissue metalloprotease inhibitor

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专利权人:

オリエンタル酵母工業株式会社

发明人:

東 昌市

申请号：

JP2010532896

公开号：

JP5651474B2

申请日:

2009.10.05

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention provides an agent capable of inhibiting MMP-2 specifically. Disclosed is a fusion molecule composed of a ²-amyloid precursor protein molecule-derived domain having an activity of selectively inhibiting matrix metalloproteinase-2 and a tissue inhibitor of metalloproteinase capable of binding to latent matrix metalloproteinase. Also disclosed are a pharmaceutical composition, a cancer metastasis and/or angiogenesis inhibitor, a therapeutic and/or prophylactic for cardiovascular diseases, and a matrix metalloproteinase-2 inhibitor, each of which comprises the fusion molecule.

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