A portable compression device for compressing at least a portion of a mammals limb is provided. The portable compression device can use mechanical compression to apply an external pressure to the portion of the limb to thereby propagate blood flow return in the direction of the mammals heart. In at least one embodiment, the portable compression device can accomplish this mechanical compression through the use of at least one frame, actuator, drum, and flexible elongate member. The actuator can move the drum between a first position and a second position. The flexible elongate member can be engaged with at least a portion of the drum and can at least partially circumscribe a portion of the limb of the mammal, such that the movement of the drum between the first and second positions can apply tension to the flexible elongate member to thereby apply a compressive force to the limb.