Amos B. SMITH,, III,Joseph SODROSKI,Navid MADANI,Bruno MELILLO,Judith M. LALONDE,Amy M. PRINCIOTTO
申请号：
US15503207
公开号：
US20170233335A1
申请日:
2015.08.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies.
