This invention relates to a composition and its use for formulating nucleic acid-based drugs/vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as miRNA, microRNA precursors, shRNAs, siRNAs, ribozymes, antisense RNAs/DNAs, RNA-DNA hybrids and DNA vectors/vaccines, with glycylated sugar alcohols/sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis. Also, the present invention discloses that chemical compounds containing sugar alcohol- and/or sugar-like structures can protect nucleic acids, in particular miRNAs, shRNAs, siRNAs and ribozymes, from degradation in vivo as well as in vitro. Therefore, the present invention is also a formula and method for preserving the structural integrity and functional efficacy of these nucleic acid-based drugs and/or vaccines in vivo and in vitro.本發明係關於一種組合物及其與糖醇組成物共同配製核酸系藥物/疫苗複合物，以供生物體外及體內遞送的使用方法。具體而言，本發明包含配製用於治療與藥學之核酸組成物的成份以及必要步驟，其中如微型核糖核酸、微型核糖核酸前驅物、小夾核糖核酸、小干擾核糖核酸、核酶、反義核糖核酸/去氧核糖核酸、核糖核酸與去氧核糖核酸之雜合物以及去氧核糖核酸載體/疫苗，係與甘胺酸化糖醇/糖構成可遞送之透過主動內噬作用於生物體內或體外由細胞吸收的複合物。再者，本發明揭示含有糖醇結構及/或似糖醇結構的化學化合物能避免核酸，特別是微型核糖核酸、小夾核糖核酸、小干擾核糖核酸及核酶在體內或體外的降解。因此，本發明也是保存該些核酸系藥物及/或疫苗在生物體內、外之結構完整性及功能有效性的配方及方法。
