Johanna Jacoba Maria Meulenberg,Monique Helene Verheije
申请号：
US11422970
公开号：
US08790656B2
申请日:
2006.06.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines and diagnostic assays obtainable by using and modifying such infectious clones of PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous microorganism.
