JOHNSON, LESLIE S.,CHICHILI, GURUNADH REDDY,SHAH, KALPANA,LA MOTTE-MOHS, ROSS,MOORE, PAUL A.,BONVINI, EZIO,KOENIG, SCOTT
申请号：
CA3006462
公开号：
CA3006462A1
申请日:
2016.12.12
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epitope of CTLA-4 (i.e., a "PD-1 x CTLA-4 bispecific molecule"). The PD-1 x CTLA-4 bispecific molecules of the present invention are capable of simultaneously binding to PD-1 and to CTLA-4, particularly as such molecules are arrayed on the surfaces of human cells. The invention is directed to pharmaceutical compositions that contain such PD-1 x CTLA-4 bispecific molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention also pertains to methods of using such PD-1 x CTLA-4 bispecific molecules to stimulate an immune response.
