Bharat Majeti,Jean-Pierre Clamme,Li Wang,Roger C. Adami,Wenbin Ying
申请号：
US16685283
公开号：
US20200157540A1
申请日:
2019.11.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.
