Barton F. HAYNES,Guido FERRARI,Scott KOENIG,Leslie S. JOHNSON,Chia-Ying Kao LAM,Julia A. SUNG,David M. MARGOLIS,Liqin LIU,Jeffrey Lee NORDSTROM
申请号：
US15514420
公开号：
US20180148497A1
申请日:
2015.09.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28, or CH44.
