UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
KLUNK, WILLIAM, E.,MATHIS, CHESTER, A., JR.,WANG, YANMING
申请号：
DK01966165
公开号：
DK1334091T3
申请日:
2001.08.24
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
This invention relates to novel thioflavin derivatives of the structure useful in, for example, in vivo imaging of patients having neuritic plaques, as well as pharmaceutical compositions comprising the thioflavin derivatives and method for synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accum ulation of neuritic plaques are prevalent. The Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
