COMPOSE DE TETRAHYDROISOQUINOLEINE, SON PROCEDE DE PREPARATION, COMPOSITION PHARMACEUTIQUE LE CONTENANT ET UTILISATION ASSOCIEE

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专利权人:

CHINESE ACADEMY OF SCIENCES;SHANGHAI INSTITUTE OF MATERIA MEDICA

发明人:

XU, YECHUN,LIU, HONG,TANG, WEI,ZHANG, XIANGLEI,GU, ZHANNI,LI, HENG,HAN, XU,ZHU, FENGHUA,FENG, CHUNLAN,DONG, GUANGYU,CHEN, TIANTIAN,CHEN, WUYAN,JIANG, HUALIANG,CHEN, KAIXIAN

申请号：

CA3090598

公开号：

CA3090598A1

申请日:

2019.02.03

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis. (I)

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