Tetrahydroisoquinoline compound, preparation method therefor, pharmaceutical composition containing same, and use thereof

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专利权人:

Chinese Academy of Sciences;Shanghai Institute of Materia Medica

发明人:

XU, Yechun,LIU, Hong,TANG, Wei,ZHANG, Xianglei,GU, Zhanni,LI, Heng,HAN, Xu,ZHU, Fenghua,FENG, Chunlan,DONG, Guangyu,CHEN, Tiantian,CHEN, Wuyan,JIANG, Hualiang,CHEN, Kaixian

申请号：

AU2019217408

公开号：

AU2019217408A1

申请日:

2019.02.03

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis. (I)

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/