NATIONAL RESEARCH COUNCIL OF CANADA;THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
发明人:
UNSWORTH, Larry, D.,LU, Lei,KULKA, Marianna
申请号:
CACA2018/050614
公开号:
WO2018/213934A1
申请日:
2018.05.25
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present disclosure relates to bioactive self-assembling peptides, nanofibers and hydrogels for activating human mast cells. The peptides, nanofibers and hydrogels comprise a self-assembling peptide that mediates self-assembly linked to a MrgX2 agonist peptide; for example, (RADA)4 linked to proadrenomedullin-12 (PAMP-12).L'invention concerne des peptides bioactifs auto-assemblés, des nanofibres et des hydrogels servant à activer des mastocytes humains. Ces peptides, nanofibres et hydrogels comprennent un peptide auto-assemblé qui induit l'auto-assemblage lié à un peptide agoniste de MrgX2 ; par exemple, (RADA)4 lié à la proadrénomédulline-12 (PAMP-12).