Presented are systems and methods that provide diagnostic measurement tools that enable even laymen to reliably and accurately perform clinical-grade diagnostic measurements of key vital signs with little or no intervention by a health care professional. In various embodiments, this is accomplished by using an automated medical diagnostic system that provides clear and concise audio/video guidance to the patient and monitors the patient's equipment usage to generate high-accuracy measurement data that may be analyzed locally and shared with health care professionals and specialists, as needed.