SOON-SHIONG, Patrick,NIAZI, Kayvan,TANAKA, Shiho,VAN LEW, Jon Thomas,OLSON, Clifford Anders
申请号：
AU2018359218
公开号：
AU2018359218A1
申请日:
2018.10.29
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Compositions, methods, and uses of recombinant recombinant IL-8 antibody, fragment thereof or single chain variable fragment (scFv) having high affinity to IL-8 to target tumor-expressed or endogenous IL-8 are presented. Preferably, the recombinant IL-8 antibody or scFv fragment includes a VH segment comprising a first amino acid sequence selected from SEQ ID NO. 1-15, 31-32, and/or a VL segment comprising a second amino acid sequence selected from SEQ ID NO. 16-30, 33-34. The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.
