WATANABE, ICHIRO,渡边一郎,渡邊一郎,HIRUMA, YOSHIHARU,昼间由晴,晝間由晴,TSUDA, EISUKE,津田英资,津田英資,MATSUOKA, TATSUJI,松冈达司,松岡達司,OHTSUKA, TOSHIAKI,大塚敏明,TAKAHASHI, TOHRU,高桥亘,高橋亘,AGATSUMA, TOSHINORI,我妻利纪,我妻利紀,MILLER, SA
申请号：
TW100135827
公开号：
TW201219568A
申请日:
2011.10.04
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.一種抑制破骨細胞之形成及/或破骨細胞之骨質再吸收的可結合Siglec-15之分離抗體或其功能片段。該抗體之重鏈包含CDRH1，該CDRH1包含與SEQ ID NO：106具至少80%序列相同度之一序列、包含與SEQ ID NO：107具至少80%序列相同度之一序列之CDRH2、及包含與SEQ ID NO：35、45、55、65或80中之一者具至少80%序列相同度之一序列CDRH3。該抗體之輕鏈包含CDRL1，該CDRL1包含與SEQ ID NO：73或83具至少80%序列相同度之一序列、包含與SEQ ID NO：108具至少80%序列相同度之一序列之CDRL2、及包含與SEQ ID NO：40、50、60、70、90、100或109中之一者具至少80%序列相同度之一序列之CDRL3。
