Antibody targeting osteoclast-related protein Siglec-15

• 收藏
• 分享

专利权人:

Kathrin-Ladetzki Baehs;Toshinori Agatsuma;Ulrike Schubert;Sandra Miller;Robert Mühlbacher;I;Tohru Takahashi;Steffen Runz;Tatsuji Matsuoka;Toshiaki Ohtsuka;Yoshiharu Hiruma;Ichiro Watanabe;Eisuke Tsuda

发明人:

Ichiro Watanabe,Yoshiharu Hiruma,Eisuke Tsuda,Tatsuji Matsuoka,Toshiaki Ohtsuka,Tohru Takahashi,Toshinori Agatsuma,Sandra Miller,Robert Mühlbacher,Kathrin-Ladetzki Baehs,Steffen Runz,Ulrike Schubert,I

申请号：

US13877779

公开号：

US09114131B2

申请日:

2011.10.04

申请国别(地区):

US

年份:

2015

代理人:

摘要：

An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/