Joseph ITSKOVITZ-ELDOR,Eyal Zussman,Lior Lowenstein,Naama Zeevi-Levin,Liron Eldor
申请号：
US13558483
公开号：
US20130030452A1
申请日:
2012.07.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided is a device comprising at least two layers, said at least two layers being at least partially overlapping (e.g., superposed) and contacting one another, wherein a first layer of said at least two layers comprises a non-biodegradable mesh, and wherein a second layer of the at least two layers comprises an electrospun element, and wherein the device is devoid of an extracellular matrix generated by mesenchymal progenitor cells, which are characterized by a reduced differentiation potential into an adipogenic lineage by at least about 50% as compared to differentiation potential of mesenchymal stem cells from an adult adipose source under identical assay conditions, and by an increased osteogenic differentiation potential by at least about 20% as compared to the osteogenic differentiation potential of adipose-derived MSCs under identical assays conditions.
